Alcoholics are more likely to skip Naltrexone doses on weekends, and it’s been theorized that they do so deliberately in order to enjoy the effects of weekend drinking. But a new study shows that Naltrexone use is actually more likely to go down on days after heavier-than-usual drinking, rather than before.
Alcoholics are also more likely to skip Naltrexone on days after they experience more intense cravings than usual.
In general, Naltrexone reduces the pleasurable effects of drinking, so it’s often been assumed that people stop taking it in anticipation of drinking in order to feel more of a “buzz.” But the study suggests that skipping doses might actually be due to the effects of having been drunk – hangovers, fuzzy thinking, and hopelessness about getting better.
The results also suggest that targeting interventions immediately after someone has lapsed into drinking or experienced heavy cravings could be effective in keeping the person on track.