Failed osteoarthritis drug could help treat opioid abuse

A drug that was created by Eli Lilly and Co. to treat osteoarthritis – and that didn’t work – could prevent tolerance in opioid users and help relieve withdrawal symptoms, scientists say.

The compound, known as LY2828360, prevented mice from developing a tolerance to morphine, according to researchers at Indiana University. The development of a tolerance (such that more and more of a drug is needed to achieve the same effect) is the reason many opioid users gradually increase their dosage, which can lead to addiction.

The researchers also found that the compound reduced the severity of opioid withdrawal symptoms.

In theory, the compound would have the same effect in humans, the researchers say, although no human trials have been set yet.

Source: Kokomo Perspective. Click here for more information.